| ACETYL OCTAPEPTIDE-3 | A peptide complex composed of the amino acids aspartic acid, glutamic acid, glutamine, and methionine, ( SNAP-8), is said to improve the look of signs of aging formed from repetitive facial expressions (3-10%). | Schagen 2017 – Topical Peptide Treatments with Effective Anti-Aging Results |
| ADENOSINE TRIPHOSPHATE | Decreases skin tone and wrinkles | Shecterle 2009 – Dermal benefits of topical D-ribose |
| ALBIZIA JULIBRISSIN BARK EXTRACT | Anti-oxidant | Jung 2003 – Antioxidant activity from the stem bark of Albizzia julibrissin |
| ARNICA MONTANA FLOWER EXTRACT | Contains Helenalin shown to reduce inflammation by inhibiting LTC4 Synthase leading to a reduction in Leukotriene production | Adkison 2010 – The effect of topical arnica on muscle pain |
| ASCORBYL PALMITATE | Skin protectrant, anti-oxidant | Meves 2002 – Vitamin C Derivative Ascorbyl Palmitate Promotes Ultraviolet-B-Induced Lipid Peroxidation and Cytotoxicity in Keratinocytes |
| AVENA SATIVA (OAT) KERNAL EXTRACT | Anti-inflammatory, moisturizing and barrier protective functions | Bergfeld 2014 – Safety Assessment of Avena sativa (Oat)-Derived Ingredients as Used in Cosmetics |
| BUTYLENE GLYCOL | | |
| CAMELLIA SINENSIS (GREEN TEA) SEED OIL | | |
| CAPRYLIC/CAPRIC TRIGLYCERIDE | | |
| CARBOMER | | |
| COCO CAPRYLATE/CAPRATE | | |
| COCONUT ALKANES | | |
| COPPER GLUCONATE | Stimulates dermal fibroblasts proliferation, and upregulates their production of collagen (types I, II, and V) and elastin fiber components (elastin, fibrillins) through the induc- tion of TGF-β. | Mahoney 2009 – Extracellular matrix in cutaneous ageing: the effects of 0.1% copper-zinc malonate-containing cream on elastin biosynthesis\n |
| CYCLOPENTASILOXANE | | |
| DEXTRAN | | |
| DISODIUM EDTA | | |
| ETHYLHEXYLGLYCERIN | | |
| FRAGRANCE | | |
| GLYCERIN | | |
| GLYCERYL STEARATE | | |
| HEMP EXTRACT (CBD) | Anti-inflammatory, topical pain reliever | Pacher 2006 – The Endocannabinoid System as an Emerging Target of Pharmacotherapy |
| HYDROLYZED MANIHOT ESCULENTA TUBER EXTRACT | | |
| HYDROLYZED OAT PROTEIN | | |
| HYDROXYPROPYL CYCLODEXTRIN | | |
| ISOPRENE GLYCOL | | |
| LAURYL/MYRISTYL BENZOATE | | |
| MAGNESIUM ASPARTATE | | |
| MALUS DOMESTICA FRUIT CELL CULTURE EXTRACT | Reduces fine lines and wrinkles | Sanz 2015 – Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs |
| MENTHOL | Reduces sensations by binding to the TRPM8 receptors also responsible for cold sensation, thus reducing pain | Pergolizzi 2018 – The role and mechanism of action of menthol in topical analgesic products |
| NIACINAMIDE | Also known as vitamin B3 and nicotinamide, niacinamide is a water-soluble vitamin that works with the natural substances in your skin to help visibly improve enlarged pores, uneven skin tone, fine lines and wrinkles, dullness, and a weakened surface and improve skin’s barrier. | Berson 2014 – Niacinamide_A Topical Vitamin with Wide-Ranging Skin Appearance Benefits |
| PALMITOYL TETRAPEPTIDE-7 | A fragment of immunoglobulin G. Palmitoyl tetrapeptide-7 decreases IL-6 secretion in a basal setting, and serves as an anti-inflammatory after exposure to UVB-irradiation | Schagen 2017 – Topical Peptide Treatments with Effective Anti-Aging Results |
| PALMITOYL TRIPEPTIDE-1 | A messenger peptide for collagen renewal, collagen and glycosaminoglycan synthesis are stimulated, the epidermis is reinforced, and wrinkles are diminished | Schagen 2017 – Topical Peptide Treatments with Effective Anti-Aging Results |
| PALMITOYL TRIPEPTIDE-37 | Anti-inflammatory and antioxidant effects, stem cell generation and wound healing properties | Schagen 2017 – Topical Peptide Treatments with Effective Anti-Aging Results |
| PALMITOYL TRIPEPTIDE-38 | Used in combination with Malus Domestica reduces crows feet and wrinkles | Sanz 2015 – Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs |
| PEG-100 STEARATE | | |
| PHENOXYETHANOL | | |
| PHOSPHOLIPIDS | | |
| PICHIA/RESVERATROL FERMENT EXTRACT | Reduces fine lines and wrinkles | 2018_03__Metabiotics Resveratrol ECT GEO_TDS_d1_lowres |
| POLYMETHYLSILSESQUIOXANE | | |
| POLYSORBATE 20 | | |
| RETINYL PALMITATE | | |
| SODIUM HYALURONATE | Promote the look of replenished facial volume by causing the skin to appear swollen/plumper, which helps reduce the look of fine lines | https://www.newdirectionsaromatics.com/blog/products/using-sodium-hyaluronate-in-skincare.html |
| SPILANTHES ACMELLA FLOWER EXTRACT | Reduces fine lines and wrinkles | Prachavasittikul 2013 – High Therapeutic Potential of Spilanthes Acmella_A Review |
| TETRAHEXYLDECYL ASCORBATE | | |
| TOCOPHERYL ACETATE | | |
| TRIBEHENIN PEG-20 ESTERS | | |
| TRIFLUOROACETYL TRIPEPTIDE-2 | Progressive effects on wrinkles, firmness, elasticity and sagging | Schagen 2017 – Topical Peptide Treatments with Effective Anti-Aging Results |
| WATER | | |
| XANTHAN GUM | | |
| ZINC GLUCONATE | Reduces fine lines and wrinkles | Gupta 2014 – Zinc Therapy in Dermatology_A Review |
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